PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2025146129A1

AssigneeBeijing Innocare Pharma Tech

TitleAmide GSPT1 degradation agent

Family ID96233774

Family members2

Filing year2024

Publication date2025-07-08

JurisdictionWO

Compounds33

Activity records89

Assays4

Activity compounds and values

Activity records

89 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
Dmax	-	=	44	%	5 mM	4 h	GSPT1	-	NB4	PGDB_A007077	PGDB_C003334	PGDB_AS000646	View
IC50	-	=	403	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A008002	PGDB_C003344	PGDB_AS000272	View
DC50	-	=	24	nM	-	—	GSPT1	-	NB4	PGDB_A011485	PGDB_C003340	PGDB_AS002359	View
DC50	-	=	55	nM	-	—	GSPT1	-	NB4	PGDB_A013219	PGDB_C003351	PGDB_AS002359	View
Dmax	-	=	74	%	5 mM	4 h	GSPT1	-	NB4	PGDB_A013511	PGDB_C003347	PGDB_AS000646	View
DC50	-	=	37	nM	-	—	GSPT1	-	NB4	PGDB_A014864	PGDB_C003356	PGDB_AS002359	View
DC50	-	=	3.7	nM	-	—	GSPT1	-	NB4	PGDB_A014981	PGDB_C003335	PGDB_AS002359	View
Dmax	-	=	86	%	5 mM	4 h	GSPT1	-	NB4	PGDB_A016049	PGDB_C003344	PGDB_AS000646	View
IC50	-	=	209	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A017357	PGDB_C003351	PGDB_AS000272	View
DC50	-	=	2	nM	-	—	GSPT1	-	NB4	PGDB_A017627	PGDB_C003354	PGDB_AS002359	View
Dmax	-	=	22	%	5 mM	4 h	GSPT1	-	NB4	PGDB_A017887	PGDB_C003336	PGDB_AS000646	View
IC50	-	=	8.6	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A018192	PGDB_C003349	PGDB_AS000272	View
DC50	-	=	14	nM	-	—	GSPT1	-	NB4	PGDB_A018863	PGDB_C003355	PGDB_AS002359	View
Dmax	-	=	128	%	5 mM	4 h	GSPT1	-	NB4	PGDB_A020146	PGDB_C003340	PGDB_AS000646	View
DC50	-	=	1.8	nM	-	—	GSPT1	-	NB4	PGDB_A020804	PGDB_C003359	PGDB_AS002359	View
IC50	-	=	16	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A021306	PGDB_C003338	PGDB_AS000272	View
Dmax	-	=	68	%	5 mM	4 h	GSPT1	-	NB4	PGDB_A021669	PGDB_C003346	PGDB_AS000646	View
DC50	-	=	17	nM	-	—	GSPT1	-	NB4	PGDB_A022189	PGDB_C003349	PGDB_AS002359	View
Dmax	-	=	91	%	5 mM	4 h	GSPT1	-	NB4	PGDB_A022573	PGDB_C003333	PGDB_AS000646	View
Dmax	-	=	117	%	5 mM	4 h	GSPT1	-	NB4	PGDB_A022622	PGDB_C003353	PGDB_AS000646	View

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