Activity record

PGDB_A022120

Assay: % DegradationTarget: NEK7QC: ambiguous
Activity overview

DC50 = 100-1000 nM

TargetNEK7
E3 ligaseCRBN
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS000280
PatentWO2025024521A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C020433
Compound IDPGDB_C020433
Compound260.0
Source record IDPGDB_C016563
InChIKeyKZANADYFQMXIQT-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000280
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
TargetNEK7
E3CRBN

Source evidence

Patent IDWO2025024521A1
Compound location

260.0

260.0 enlarged structure260.0 location on patent page 87
Activity table
Page 416 · table start
Page 417 · table middle
Page 418 · table end