Activity record

PGDB_A022710

Assay: cellular_functionTarget: BRD4QC: ambiguous
Activity overview

EC50 = 1.347 uM

TargetBRD4
E3 ligaseCRBN
Cell lineFlip-InTM293
Time5 h
Assay / Readoutflow_cytometry / EC50
Assay IDPGDB_AS001859
PatentUS12110292B2
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C009009
Compound IDPGDB_C009009
Compound24;24;24
Source record IDPGDB_C009009
InChIKeyKCIIVRZRNLZKQA-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001859
Assay familycellular_function
Assay systemcell_based
ReadoutEC50
Technologyflow_cytometry
Treatment time5 h
TargetBRD4
E3CRBN
Cell lineFlip-InTM293
Organismmammalian

Source evidence

Patent IDUS12110292B2
Compound location

24;24;24

24;24;24 enlarged structure24;24;24 location on patent page 29
Activity table
Page 102 · table start
Page 103 · table end