PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberUS12110292B2

AssigneeDana Farber Cancer Institute

TitleLigands to cereblon (CRBN)

Family ID68987146

Family members18

Filing year2022

Publication date2024-10-08

JurisdictionUS

Compounds47

Activity records66

Assays3

Activity compounds and values

Activity records

66 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
EC50	-	=	0.742	uM	-	—	BRD4	CRBN	Flip-InTM293	PGDB_A010131	PGDB_C009022	PGDB_AS001859	View
IC50	-	=	18.9	uM	-	—	CRBN	CRBN	-	PGDB_A010797	PGDB_C008996	PGDB_AS001311	View
IC50	-	=	15.2	uM	-	—	CRBN	CRBN	-	PGDB_A013564	PGDB_C009001	PGDB_AS001311	View
Ki	-	=	3.9	uM	-	—	CRBN	CRBN	-	PGDB_A014004	PGDB_C008998	PGDB_AS002388	View
EC50	-	=	8.138	uM	-	—	BRD4	CRBN	Flip-InTM293	PGDB_A017047	PGDB_C009013	PGDB_AS001859	View
EC50	-	=	8.146	uM	-	—	BRD4	CRBN	Flip-InTM293	PGDB_A017683	PGDB_C009014	PGDB_AS001859	View
EC50	-	=	3.63	uM	-	—	BRD4	CRBN	Flip-InTM293	PGDB_A017721	PGDB_C009005	PGDB_AS001859	View
EC50	-	=	8.29	uM	-	—	BRD4	CRBN	Flip-InTM293	PGDB_A018937	PGDB_C009030	PGDB_AS001859	View
Ki	-	=	0.44	uM	-	—	CRBN	CRBN	-	PGDB_A020041	PGDB_C009000	PGDB_AS002388	View
EC50	-	=	0.665	uM	-	—	BRD4	CRBN	Flip-InTM293	PGDB_A020231	PGDB_C009033	PGDB_AS001859	View
EC50	-	=	0.66	uM	-	—	BRD4	CRBN	Flip-InTM293	PGDB_A021281	PGDB_C009008	PGDB_AS001859	View
Ki	-	=	4.3	uM	-	—	CRBN	CRBN	-	PGDB_A021458	PGDB_C009001	PGDB_AS002388	View
EC50	-	=	12.45	uM	-	—	BRD4	CRBN	Flip-InTM293	PGDB_A022657	PGDB_C009028	PGDB_AS001859	View
EC50	-	=	1.347	uM	-	—	BRD4	CRBN	Flip-InTM293	PGDB_A022710	PGDB_C009009	PGDB_AS001859	View
IC50	-	=	38.9	uM	-	—	CRBN	CRBN	-	PGDB_A023526	PGDB_C008994	PGDB_AS001311	View
Ki	-	=	6.5	uM	-	—	CRBN	CRBN	-	PGDB_A023556	PGDB_C008993	PGDB_AS002388	View
EC50	-	=	1.246	uM	-	—	BRD4	CRBN	Flip-InTM293	PGDB_A026544	PGDB_C009011	PGDB_AS001859	View
IC50	-	=	47.5	uM	-	—	CRBN	CRBN	-	PGDB_A028459	PGDB_C008989	PGDB_AS001311	View
EC50	-	=	2.24	uM	-	—	BRD4	CRBN	Flip-InTM293	PGDB_A028469	PGDB_C009019	PGDB_AS001859	View
EC50	-	=	1.264	uM	-	—	BRD4	CRBN	Flip-InTM293	PGDB_A028835	PGDB_C009006	PGDB_AS001859	View

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