Activity record

PGDB_A025347

Assay: % DegradationTarget: GSPT1QC: standardized
Activity overview

DC50 = 2.5 nM

TargetGSPT1
Cell lineHEK293
Time24 h
Assay / ReadoutDC50 / % Degradation
Assay IDPGDB_AS000196
PatentWO2025252247A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C005473
Compound IDPGDB_C005473
Compound实施例 21;实施例 21
Source record IDPGDB_C005473
InChIKeyZCQUXCHQNHVHFY-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000196
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Treatment time24 h
Detection targetprotein_degradation
TargetGSPT1
E3Not specified
Cell lineHEK293

Source evidence

Patent IDWO2025252247A1
Compound location

实施例 21;实施例 21

实施例 21;实施例 21 enlarged structure实施例 21;实施例 21 location on patent page 72
Activity table
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