Activity record

PGDB_A026630

Assay: % DegradationTarget: IKZF1QC: standardized
Activity overview

DC50 = 0.17 nM

TargetIKZF1
E3 ligaseCRBN
Cell lineHT-1080
Time20 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS001276
PatentWO2023025136A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C009987
Compound IDPGDB_C009987
Compound化合物 1-B
Source record IDPGDB_C009987
InChIKeyRIUZYGZRTWXCOM-CUBQBAPOSA-N

Assay context

Assay IDPGDB_AS001276
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time20 h
TargetIKZF1
E3CRBN
Cell lineHT-1080
OrganismHomo sapiens

Source evidence

Patent IDWO2023025136A1
Compound location

化合物 1-B

化合物 1-B enlarged structure化合物 1-B location on patent page 61
Activity table
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