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Patent
WO2023025136A1
19 compounds85 activity records6 assays
Patent summary
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | DC50 | - | = | 0.332 | uM | - | — | SALL4 | - | HT-1080 | PGDB_A008079 | PGDB_C009601 | PGDB_AS001426 | View |
 | Dmax | - | = | 63.1 | % | Concentration series: 0.316 nM, 10 uM | 20 h | SALL4 | CRBN | HT-1080 | PGDB_A008114 | PGDB_C009992 | PGDB_AS001792 | View |
 | DC50 | - | = | 0.0033 | uM | - | — | SALL4 | - | HT-1080 | PGDB_A008679 | PGDB_C009995 | PGDB_AS001426 | View |
 | Dmax | - | = | 90.6 | % | Concentration series: 0.316 nM, 10 uM | 20 h | IKZF1 | CRBN | HT-1080 | PGDB_A010378 | PGDB_C010001 | PGDB_AS000619 | View |
| IC50 | - | = | 30 | nM | - | — | - | - | MM.1S | PGDB_A011009 | PGDB_C009601 | PGDB_AS001243 | View |
 | Dmax | - | = | 90.4 | % | Concentration series: 0.316 nM, 10 uM | 20 h | IKZF1 | CRBN | HT-1080 | PGDB_A011406 | PGDB_C009998 | PGDB_AS000619 | View |
| Dmax | - | = | 69.7 | % | Concentration series: 0.316 nM, 10 uM | 20 h | SALL4 | CRBN | HT-1080 | PGDB_A011674 | PGDB_C009601 | PGDB_AS001792 | View |
 | DC50 | - | = | 0.047 | nM | - | — | IKZF1 | CRBN | HT-1080 | PGDB_A012607 | PGDB_C009985 | PGDB_AS001276 | View |
 | Dmax | - | = | 46.8 | % | Concentration series: 0.316 nM, 10 uM | 20 h | SALL4 | CRBN | HT-1080 | PGDB_A014325 | PGDB_C009996 | PGDB_AS001792 | View |
 | IC50 | - | = | 0.03 | nM | - | — | - | - | MM.1S | PGDB_A014969 | PGDB_C009997 | PGDB_AS001243 | View |
| DC50 | - | = | 0.052 | nM | - | — | IKZF1 | CRBN | HT-1080 | PGDB_A015550 | PGDB_C009995 | PGDB_AS001276 | View |
 | Dmax | - | = | 65.7 | % | Concentration series: 0.316 nM, 10 uM | 20 h | SALL4 | CRBN | HT-1080 | PGDB_A015748 | PGDB_C009988 | PGDB_AS001792 | View |
| DC50 | - | = | 0.44 | nM | - | — | IKZF1 | CRBN | HT-1080 | PGDB_A016456 | PGDB_C009997 | PGDB_AS001276 | View |
| DC50 | - | = | 0.068 | nM | - | — | IKZF1 | CRBN | HT-1080 | PGDB_A016469 | PGDB_C009992 | PGDB_AS001276 | View |
| Dmax | - | = | 49.2 | % | Concentration series: 0.316 nM, 10 uM | 20 h | SALL4 | CRBN | HT-1080 | PGDB_A018285 | PGDB_C010001 | PGDB_AS001792 | View |
 | DC50 | - | > | 10 | uM | - | — | SALL4 | - | HT-1080 | PGDB_A018733 | PGDB_C009993 | PGDB_AS001426 | View |
| Dmax | - | = | 88.7 | % | Concentration series: 0.316 nM, 10 uM | 20 h | IKZF1 | CRBN | HT-1080 | PGDB_A019231 | PGDB_C009996 | PGDB_AS000619 | View |
| Ymin | - | = | 3.7 | % | Concentration series: 0.316 pM, 10 nM | 120 h | - | - | MM.1S | PGDB_A019601 | PGDB_C009985 | PGDB_AS000580 | View |
| Dmax | - | = | 40.9 | % | Concentration series: 0.316 nM, 10 uM | 20 h | SALL4 | CRBN | HT-1080 | PGDB_A020049 | PGDB_C009998 | PGDB_AS001792 | View |
 | Ymin | - | = | 5.6 | % | Concentration series: 0.316 pM, 10 nM | 120 h | - | - | MM.1S | PGDB_A020172 | PGDB_C009989 | PGDB_AS000580 | View |