PatGlueDB | Molecular Glue Patent Bioactivity Database

Assay context summary

Assay context

19 activity records

Assay family% Degradation

Systemcell_based

ReadoutDC50

TargetIKZF1

E3CRBN

Cell lineHT-1080

OrganismHomo sapiens

Technologyluminescence

Activity compounds and values

Activity records

19 records

Metric	Control	Relation	Value	Unit	Concentration	Time	Target	E3	Cell line	Patent	Record ID	Compound	Assay	Details
DC50	-	=	0.047	nM	-	—	IKZF1	CRBN	HT-1080	WO2023025136A1	PGDB_A012607	PGDB_C009985	PGDB_AS001276	View
DC50	-	=	0.052	nM	-	—	IKZF1	CRBN	HT-1080	WO2023025136A1	PGDB_A015550	PGDB_C009995	PGDB_AS001276	View
DC50	-	=	0.44	nM	-	—	IKZF1	CRBN	HT-1080	WO2023025136A1	PGDB_A016456	PGDB_C009997	PGDB_AS001276	View
DC50	-	=	0.068	nM	-	—	IKZF1	CRBN	HT-1080	WO2023025136A1	PGDB_A016469	PGDB_C009992	PGDB_AS001276	View
DC50	-	=	0.17	nM	-	—	IKZF1	CRBN	HT-1080	WO2023025136A1	PGDB_A026630	PGDB_C009987	PGDB_AS001276	View
DC50	-	=	0.071	nM	-	—	IKZF1	CRBN	HT-1080	WO2023025136A1	PGDB_A026942	PGDB_C009989	PGDB_AS001276	View
DC50	-	=	0.12	nM	-	—	IKZF1	CRBN	HT-1080	WO2023025136A1	PGDB_A034259	PGDB_C010001	PGDB_AS001276	View
DC50	-	=	0.11	nM	-	—	IKZF1	CRBN	HT-1080	WO2023025136A1	PGDB_A034400	PGDB_C009991	PGDB_AS001276	View
DC50	-	=	0.36	nM	-	—	IKZF1	CRBN	HT-1080	WO2023025136A1	PGDB_A037010	PGDB_C009998	PGDB_AS001276	View
DC50	-	<	0.18	nM	-	—	IKZF1	CRBN	HT-1080	WO2023025136A1	PGDB_A040674	PGDB_C009990	PGDB_AS001276	View
DC50	-	=	0.71	nM	-	—	IKZF1	CRBN	HT-1080	WO2023025136A1	PGDB_A048017	PGDB_C009988	PGDB_AS001276	View
DC50	-	<	0.18	nM	-	—	IKZF1	CRBN	HT-1080	WO2023025136A1	PGDB_A051344	PGDB_C009994	PGDB_AS001276	View
DC50	-	=	0.266	nM	-	—	IKZF1	CRBN	HT-1080	WO2023025136A1	PGDB_A052679	PGDB_C009601	PGDB_AS001276	View
DC50	-	=	1.28	nM	-	—	IKZF1	CRBN	HT-1080	WO2023025136A1	PGDB_A062010	PGDB_C009996	PGDB_AS001276	View
DC50	-	=	1.22	nM	-	—	IKZF1	CRBN	HT-1080	WO2023025136A1	PGDB_A062491	PGDB_C010002	PGDB_AS001276	View
DC50	-	=	0.18	nM	-	—	IKZF1	CRBN	HT-1080	WO2023025136A1	PGDB_A071134	PGDB_C010000	PGDB_AS001276	View
DC50	-	=	0.21	nM	-	—	IKZF1	CRBN	HT-1080	WO2023025136A1	PGDB_A071428	PGDB_C009999	PGDB_AS001276	View
DC50	-	=	0.042	nM	-	—	IKZF1	CRBN	HT-1080	WO2023025136A1	PGDB_A072643	PGDB_C009986	PGDB_AS001276	View
DC50	-	=	0.14	nM	-	—	IKZF1	CRBN	HT-1080	WO2023025136A1	PGDB_A073300	PGDB_C009993	PGDB_AS001276	View

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