Activity record

PGDB_A027395

Assay: % DegradationTarget: BRAFQC: standardized
Activity overview

Emax = 15.74 %

TargetBRAF
Cell lineA375.10
Concentration10 uM
Time24 h
Assay / Readoutluminescence / Emax
Assay IDPGDB_AS000014
PatentAU2022290851A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C005692
Compound IDPGDB_C005692
CompoundExample 39
Source record IDPGDB_C005692
InChIKeyZMQPEPYPOGMLRB-CLLIMVSLSA-N

Assay context

Assay IDPGDB_AS000014
Assay family% Degradation
Assay systemcell_based
ReadoutEmax
Technologyluminescence
Concentration10 uM
Treatment time24 h
TargetBRAF
E3Not specified
Cell lineA375.10

Source evidence

Patent IDAU2022290851A1
Compound location

Example 39

Example 39 enlarged structureExample 39 location on patent page 381
Activity table
Page 228 · table start