Activity record

PGDB_A030212

Assay: bindingTarget: CRBNQC: standardized
Activity overview

IC50 = 0.517 uM

TargetCRBN
E3 ligaseCRBN
Time60 min
Assay / Readoutfluorescence / IC50
Assay IDPGDB_AS001311
PatentUS12110292B2
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C009002
Compound IDPGDB_C009002
Compound16
Source record IDPGDB_C009002
InChIKeyDUXOGWVIPNJZCP-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001311
Assay familybinding
Assay systembiochemical
ReadoutIC50
Technologyfluorescence
Treatment time60 min
TargetCRBN | DDB1
E3CRBN | DDB1

Source evidence

Patent IDUS12110292B2
Compound location

16

16 enlarged structure16 location on patent page 65
Activity table
Page 102 · table start
Page 103 · table end