Activity record

PGDB_A031373

Assay: % DegradationTarget: GSPT1QC: standardized
Activity overview

DC50 = 4.9 nM

TargetGSPT1
Cell lineHEK293
Time24 h
Assay / ReadoutDC50 / % Degradation
Assay IDPGDB_AS000196
PatentWO2025252247A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C005468
Compound IDPGDB_C005468
Compound化合物16;实施例 16;实施例 16
Source record IDPGDB_C005468
InChIKeyIMTONKYULMDQEV-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000196
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Treatment time24 h
Detection targetprotein_degradation
TargetGSPT1
E3Not specified
Cell lineHEK293

Source evidence

Patent IDWO2025252247A1
Compound location

化合物16;实施例 16;实施例 16

化合物16;实施例 16;实施例 16 enlarged structure化合物16;实施例 16;实施例 16 location on patent page 108
Activity table
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