Activity record

PGDB_A031837

Assay: % DegradationTarget: BRAFQC: standardized
Activity overview

DC50 = 8.13 nM

TargetBRAF
Cell lineA375.10
Time24 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS001091
PatentAU2022290851A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C005693
Compound IDPGDB_C005693
CompoundExample 40
Source record IDPGDB_C005693
InChIKeyKUKQPXQWBSIDQC-HQHHGIPJSA-N

Assay context

Assay IDPGDB_AS001091
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time24 h
TargetBRAF
E3Not specified
Cell lineA375.10

Source evidence

Patent IDAU2022290851A1
Compound location

Example 40

Example 40 enlarged structureExample 40 location on patent page 382
Activity table
Page 228 · table start