Activity record

PGDB_A033294

Assay: % DegradationTarget: NEK7QC: ambiguous
Activity overview

DC50 < 100 nM

TargetNEK7
E3 ligaseCRBN
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS000280
PatentWO2025024521A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C020357
Compound IDPGDB_C020357
Compound184;184
Source record IDPGDB_C016487
InChIKeyMTCVKWDFSQMZBZ-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000280
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
TargetNEK7
E3CRBN

Source evidence

Patent IDWO2025024521A1
Compound location

184;184

184;184 enlarged structure184;184 location on patent page 84
Activity table
Page 416 · table start
Page 417 · table middle
Page 418 · table end