Activity record

PGDB_A033384

Assay: % DegradationTarget: IKZF3QC: standardized
Activity overview

DC50 <= 10 nM

TargetIKZF3
E3 ligaseCRBN
Time24 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS002421
PatentWO2025195464A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C011568
Compound IDPGDB_C011568
CompoundCM-246
Source record IDPGDB_C011568
InChIKeyRNYPTXPNHXDDRI-XEGCMXMBSA-N

Assay context

Assay IDPGDB_AS002421
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time24 h
Detection targetprotein_degradation
TargetIKZF3
E3CRBN
OrganismHomo sapiens

Source evidence

Patent IDWO2025195464A1
Compound location

CM-246

CM-246 enlarged structureCM-246 location on patent page 139
Activity table
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