Activity record

PGDB_A034170

Assay: % DegradationTarget: GSPT1QC: standardized
Activity overview

degradation = 20-40 %

TargetGSPT1
Cell lineMV-4-11
Concentration10 nM
Time6 h
Assay / ReadoutWestern_blot / % Degradation
Assay IDPGDB_AS000838
PatentCN120289428A
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C000705
Compound IDPGDB_C000705
Compound实施例12
Source record IDPGDB_C000705
InChIKeyGAKAQJDFHUGMNU-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000838
Assay family% Degradation
Assay systemcell_based
Readout% Degradation
TechnologyWestern_blot
Concentration10 nM
Treatment time6 h
Detection targetprotein_degradation
TargetGSPT1
E3Not specified
Cell lineMV-4-11

Source evidence

Patent IDCN120289428A
Compound location

实施例12

实施例12 enlarged structure实施例12 location on patent page 41
Activity table
Page 60 · table single