PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN120289428A

AssigneePu Meirui Suzhou Biotechnology, Shandong Longchen Pharmaceutical, Suzhou Medinoah

TitleA 1-oxoisoindoline derivative and its application

Family ID96268432

Family members1

Filing year2025

Publication date2025-07-11

JurisdictionCN

Compounds38

Activity records47

Assays2

Activity compounds and values

Activity records

47 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Degradation	-	=	40-60	%	10 nM	6 h	GSPT1	-	MV-4-11	PGDB_A007304	PGDB_C000715	PGDB_AS000838	View
% Degradation	-	=	40-60	%	10 nM	6 h	GSPT1	-	MV-4-11	PGDB_A008966	PGDB_C000732	PGDB_AS000838	View
% Degradation	-	=	40-60	%	10 nM	6 h	GSPT1	-	MV-4-11	PGDB_A009112	PGDB_C000702	PGDB_AS000838	View
% Degradation	-	=	60-80	%	10 nM	6 h	GSPT1	-	MV-4-11	PGDB_A009231	PGDB_C000708	PGDB_AS000838	View
% Degradation	-	=	60-80	%	10 nM	6 h	GSPT1	-	MV-4-11	PGDB_A009287	PGDB_C000711	PGDB_AS000838	View
% Degradation	-	=	40-60	%	10 nM	6 h	GSPT1	-	MV-4-11	PGDB_A010308	PGDB_C000719	PGDB_AS000838	View
% Degradation	-	=	80-100	%	10 nM	6 h	GSPT1	-	MV-4-11	PGDB_A011160	PGDB_C000700	PGDB_AS000838	View
IC50	-	=	<= 3	nM	-	—	GSPT1	-	MV-4-11	PGDB_A013490	PGDB_C000716	PGDB_AS002456	View
IC50	-	=	<= 3	nM	-	—	GSPT1	-	MV-4-11	PGDB_A015530	PGDB_C000725	PGDB_AS002456	View
% Degradation	-	=	60-80	%	10 nM	6 h	GSPT1	-	MV-4-11	PGDB_A016068	PGDB_C000714	PGDB_AS000838	View
% Degradation	-	=	20-40	%	10 nM	6 h	GSPT1	-	MV-4-11	PGDB_A019537	PGDB_C000733	PGDB_AS000838	View
% Degradation	-	=	40-60	%	10 nM	6 h	GSPT1	-	MV-4-11	PGDB_A020379	PGDB_C000717	PGDB_AS000838	View
IC50	-	=	> 3-5	nM	-	—	GSPT1	-	MV-4-11	PGDB_A021538	PGDB_C000708	PGDB_AS002456	View
IC50	-	=	> 20-30	nM	-	—	GSPT1	-	MV-4-11	PGDB_A028240	PGDB_C000707	PGDB_AS002456	View
% Degradation	-	=	80-100	%	10 nM	6 h	GSPT1	-	MV-4-11	PGDB_A030058	PGDB_C000727	PGDB_AS000838	View
% Degradation	-	=	60-80	%	10 nM	6 h	GSPT1	-	MV-4-11	PGDB_A031714	PGDB_C000731	PGDB_AS000838	View
% Degradation	-	=	40-60	%	10 nM	6 h	GSPT1	-	MV-4-11	PGDB_A032581	PGDB_C000709	PGDB_AS000838	View
IC50	-	=	> 3-5	nM	-	—	GSPT1	-	MV-4-11	PGDB_A034055	PGDB_C000713	PGDB_AS002456	View
% Degradation	-	=	20-40	%	10 nM	6 h	GSPT1	-	MV-4-11	PGDB_A034170	PGDB_C000705	PGDB_AS000838	View
% Degradation	-	=	40-60	%	10 nM	6 h	GSPT1	-	MV-4-11	PGDB_A036562	PGDB_C000723	PGDB_AS000838	View

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