Activity record

PGDB_A039806

Assay: biochemicalTarget: CRBNQC: standardized
Activity overview

IC50 = 0.5-1 uM

TargetCRBN
E3 ligaseCRBN
Time3 h
Assay / ReadoutHTRF / IC50
Assay IDPGDB_AS001897
PatentWO2025016359A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C019193
Compound IDPGDB_C019193
CompoundGT-04452
Source record IDPGDB_C019193
InChIKeyYRPJYWOKFDNOFY-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001897
Assay familybiochemical
Assay systembiochemical
ReadoutIC50
TechnologyHTRF
Treatment time3 h
TargetCRBN
E3CRBN
OrganismHomo sapiens

Source evidence

Patent IDWO2025016359A1
Compound location

GT-04452

GT-04452 enlarged structureGT-04452 location on patent page 19
Activity table
Page 214 · table start
Page 215 · table middle
Page 216 · table end