Activity record

PGDB_A040140

Assay: % DegradationQC: standardized
Activity overview

DC50 = 0.98 nM

Cell lineNCI-H929
Time24 h
Assay / ReadoutWestern_blot / DC50
Assay IDPGDB_AS001024
PatentEP4685141A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C025619
Compound IDPGDB_C025619
Compound实施例 25
Source record IDPGDB_C025619
InChIKeyHDAAFKBDUXDETD-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001024
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
TechnologyWestern_blot
Treatment time24 h
Detection targetprotein_degradation
TargetIKZF1
E3Not specified
Cell lineNCI-H929
OrganismHomo sapiens

Source evidence

Patent IDEP4685141A1
Compound location

实施例 25

实施例 25 enlarged structure实施例 25 location on patent page 50
Activity table
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