Activity record

PGDB_A042654

Assay: biochemicalTarget: CRBNQC: ambiguous
Activity overview

inhibition = 20-30 %

TargetCRBN
E3 ligaseCRBN
Concentration0.5 uM
Time3 h
Assay / ReadoutHTRF / Kd
Assay IDPGDB_AS001495
PatentWO2024245444A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C023635
Compound IDPGDB_C023635
CompoundGT-08177
Source record IDPGDB_C014208
InChIKeyZAMUCNDCANOXHY-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001495
Assay familybiochemical
Assay systemcell_based
ReadoutKd
TechnologyHTRF
Concentration0.5 uM
Treatment time3 h
TargetCRBN
E3CRBN
OrganismHomo sapiens

Source evidence

Patent IDWO2024245444A1
Compound location

GT-08177

GT-08177 enlarged structureGT-08177 location on patent page 80
Activity table
Page 260 · table single