PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2024245444A1

AssigneeGluetacs Therapeutics Shanghai

TitleOxoisoindolyl-substituted tetrahydropyrimidinedione derivatives and their applications

Family ID93656755

Family members2

Filing year2024

Publication date2025-02-14

JurisdictionWO

Compounds399

Activity records2,824

Assays23

Activity compounds and values

Activity records

2,824 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	PGDB_A007007	PGDB_C014291	PGDB_AS001967	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	PGDB_A007036	PGDB_C020095	PGDB_AS002298	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	PGDB_A007105	PGDB_C020068	PGDB_AS001137	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	PGDB_A007138	PGDB_C020040	PGDB_AS001967	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	PGDB_A007160	PGDB_C023622	PGDB_AS000969	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	PGDB_A007225	PGDB_C019953	PGDB_AS002298	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	PGDB_A007227	PGDB_C014264	PGDB_AS000969	View
% Inhibition	-	=	20-40	%	500 nM	-	-	-	H292	PGDB_A007239	PGDB_C023699	PGDB_AS000415	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	PGDB_A007244	PGDB_C023618	PGDB_AS000339	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	PGDB_A007275	PGDB_C020042	PGDB_AS002298	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	PGDB_A007317	PGDB_C020075	PGDB_AS002298	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	PGDB_A007353	PGDB_C020059	PGDB_AS001137	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	PGDB_A007372	PGDB_C020102	PGDB_AS000969	View
IC50	-	=	100-500	nM	-	—	-	-	MM.1S	PGDB_A007374	PGDB_C014217	PGDB_AS001978	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	PGDB_A007385	PGDB_C019941	PGDB_AS002298	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MM.1S	PGDB_A007400	PGDB_C023632	PGDB_AS000503	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	PGDB_A007431	PGDB_C020127	PGDB_AS001967	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	PGDB_A007435	PGDB_C014248	PGDB_AS001137	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	PGDB_A007472	PGDB_C020066	PGDB_AS001137	View
IC50	-	=	100-500	nM	-	—	-	-	MM.1S	PGDB_A007491	PGDB_C014226	PGDB_AS001978	View

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