Activity record

PGDB_A043280

Assay: % DegradationTarget: CDK2QC: standardized
Activity overview

IC50 = 0.17 uM

TargetCDK2
Cell lineHEK293
Time6 h
Assay / Readoutluminescence / IC50
Assay IDPGDB_AS000366
PatentWO2025043225
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C008045
Compound IDPGDB_C008045
Compound64;64;64
Source record IDPGDB_C008045
InChIKeyGNSXVNYVOYTDFN-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000366
Assay family% Degradation
Assay systemcell_based
ReadoutIC50
Technologyluminescence
Treatment time6 h
Detection targetprotein_degradation
TargetCDK2
E3Not specified
Cell lineHEK293

Source evidence

Patent IDWO2025043225
Compound location

64;64;64

64;64;64 enlarged structure64;64;64 location on patent page 40
Activity table
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