Activity record

PGDB_A043422

Assay: % DegradationTarget: IKZF1QC: standardized
Activity overview

DC50 = 0.74 nM

TargetIKZF1
Cell lineHT-1080
Time20 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS001653
PatentEP4393915A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C007548
Compound IDPGDB_C007548
Compound化合物 6
Source record IDPGDB_C007548
InChIKeyLLMDJSWDMLTPFA-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001653
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time20 h
Detection targetprotein_degradation
TargetIKZF1
E3Not specified
Cell lineHT-1080
OrganismHomo sapiens

Source evidence

Patent IDEP4393915A1
Compound location

化合物 6

化合物 6 enlarged structure化合物 6 location on patent page 106
Activity table
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