Assay

PGDB_AS001653

System: cell_basedTarget: IKZF1Cell line: HT-1080
Assay context summary

Assay context

16 activity records
Assay family% Degradation
Systemcell_based
ReadoutDC50
TargetIKZF1
E3Not specified
Cell lineHT-1080
OrganismHomo sapiens
Technologyluminescence
Detection targetprotein_degradation
Activity compounds and values

Activity records

16 records
StructureMetricControlRelationValueUnitConcentrationTimeTargetE3Cell linePatentRecord IDCompoundAssayDetails
2D structure for PGDB_C007552
DC50-=0.23nM-—IKZF1-HT-1080EP4393915A1PGDB_A014100PGDB_C007552PGDB_AS001653View
2D structure for PGDB_C007556
DC50-=5.89nM-—IKZF1-HT-1080EP4393915A1PGDB_A015086PGDB_C007556PGDB_AS001653View
2D structure for PGDB_C007547
DC50-=0.017nM-—IKZF1-HT-1080EP4393915A1PGDB_A015094PGDB_C007547PGDB_AS001653View
2D structure for PGDB_C007545
DC50-=0.038nM-—IKZF1-HT-1080EP4393915A1PGDB_A016823PGDB_C007545PGDB_AS001653View
2D structure for PGDB_C007555
DC50-=2.19nM-—IKZF1-HT-1080EP4393915A1PGDB_A019854PGDB_C007555PGDB_AS001653View
2D structure for PGDB_C007543
DC50-=0.025nM-—IKZF1-HT-1080EP4393915A1PGDB_A023054PGDB_C007543PGDB_AS001653View
2D structure for PGDB_C007551
DC50-=0.074nM-—IKZF1-HT-1080EP4393915A1PGDB_A027666PGDB_C007551PGDB_AS001653View
2D structure for PGDB_C007554
DC50-=0.065nM-—IKZF1-HT-1080EP4393915A1PGDB_A028472PGDB_C007554PGDB_AS001653View
2D structure for PGDB_C007557
DC50-=1.22nM-—IKZF1-HT-1080EP4393915A1PGDB_A034183PGDB_C007557PGDB_AS001653View
2D structure for PGDB_C009601
DC50-=0.266nM-—IKZF1-HT-1080EP4393915A1PGDB_A035093PGDB_C009601PGDB_AS001653View
2D structure for PGDB_C007549
DC50-=0.13nM-—IKZF1-HT-1080EP4393915A1PGDB_A038996PGDB_C007549PGDB_AS001653View
2D structure for PGDB_C007548
DC50-=0.74nM-—IKZF1-HT-1080EP4393915A1PGDB_A043422PGDB_C007548PGDB_AS001653View
2D structure for PGDB_C007544
DC50-=0.022nM-—IKZF1-HT-1080EP4393915A1PGDB_A052145PGDB_C007544PGDB_AS001653View
2D structure for PGDB_C007546
DC50-=0.026nM-—IKZF1-HT-1080EP4393915A1PGDB_A059427PGDB_C007546PGDB_AS001653View
2D structure for PGDB_C007550
DC50-=2.37nM-—IKZF1-HT-1080EP4393915A1PGDB_A067162PGDB_C007550PGDB_AS001653View
2D structure for PGDB_C007553
DC50-=0.134nM-—IKZF1-HT-1080EP4393915A1PGDB_A077740PGDB_C007553PGDB_AS001653View
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