Activity record

PGDB_A044445

Assay: % DegradationTarget: IKZF2QC: ambiguous
Activity overview

DC50 = 2.9 nM

TargetIKZF2
Time20 h
Assay / Readoutflow_cytometry / DC50
Assay IDPGDB_AS001597
PatentWO2025064197
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C007381
Compound IDPGDB_C007381
CompoundComparative Compound A
Source record IDPGDB_C007381
InChIKeyOHSPSWUQMQUVMW-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001597
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyflow_cytometry
Treatment time20 h
Detection targetprotein_degradation
TargetIKZF2
E3Not specified
OrganismHomo sapiens

Source evidence

Patent IDWO2025064197
Compound location

Comparative Compound A

Comparative Compound A enlarged structureComparative Compound A location on patent page 86
Activity table
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