PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2025064197

AssigneeBristol Myers Squibb

TitleSubstituted azetidinyl oxoisoindolinyl piperidine-2,6-dione compounds

Family ID92843372

Family members1

Filing year2024

Publication date2025-03-27

JurisdictionWO

Compounds6

Activity records156

Assays26

Activity compounds and values

Activity records

156 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
DC50	-	=	32	nM	-	—	IKZF1	-	-	PGDB_A007528	PGDB_C010131	PGDB_AS000591	View
Dmax	-	=	77	%	-	24 h	-	-	primary human PBMC	PGDB_A007957	PGDB_C010133	PGDB_AS000355	View
DC50	-	=	30	nM	-	—	IKZF2	-	Jurkat	PGDB_A008183	PGDB_C010133	PGDB_AS001529	View
Dmax	-	=	95	%	Concentration context: titrated doses	13 d	IKZF4	-	-	PGDB_A008838	PGDB_C007382	PGDB_AS000221	View
Dmax	-	=	80	%	-	24 h	IKZF1	-	-	PGDB_A009823	PGDB_C010133	PGDB_AS002368	View
DC50	-	>	10000	nM	-	—	IKZF3	-	Jurkat	PGDB_A010419	PGDB_C007382	PGDB_AS002122	View
Dmax	-	=	86	%	-	24 h	IKZF1	-	-	PGDB_A011216	PGDB_C010130	PGDB_AS002368	View
Dmax	-	=	68	%	-	24 h	IKZF3	-	-	PGDB_A011285	PGDB_C010132	PGDB_AS000033	View
DC50	-	>	6136	nM	-	—	IKZF3	-	Jurkat	PGDB_A012629	PGDB_C010132	PGDB_AS002122	View
Dmax	-	=	37	%	-	24 h	IKZF3	-	Jurkat	PGDB_A012888	PGDB_C010133	PGDB_AS002580	View
Dmax	-	=	97	%	-	20 h	IKZF2	-	-	PGDB_A013616	PGDB_C007382	PGDB_AS001254	View
Dmax	-	=	33	%	-	20 h	IKZF4	-	-	PGDB_A015243	PGDB_C010132	PGDB_AS001958	View
DC50	-	=	16	nM	-	—	IKZF1	-	-	PGDB_A015607	PGDB_C010130	PGDB_AS000591	View
Dmax	-	=	39	%	-	20 h	IKZF3	-	-	PGDB_A016044	PGDB_C010130	PGDB_AS001828	View
DC50	-	=	1	nM	-	—	IKZF4	-	-	PGDB_A016585	PGDB_C010133	PGDB_AS001710	View
Dmax	-	=	100	%	-	20 h	IKZF2	-	-	PGDB_A016865	PGDB_C010130	PGDB_AS001254	View
DC50	-	=	1	nM	-	—	IKZF4	-	-	PGDB_A017498	PGDB_C007382	PGDB_AS001710	View
DC50	-	>	10000	nM	-	—	IKZF3	-	-	PGDB_A019723	PGDB_C010133	PGDB_AS001891	View
Dmax	-	=	64	%	-	20 h	IKZF4	-	-	PGDB_A019959	PGDB_C007381	PGDB_AS001958	View
DC50	-	>	10000	nM	-	—	IKZF4	-	-	PGDB_A020289	PGDB_C010130	PGDB_AS001282	View

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