PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3c(ccc(-c4cc(CN5CC(c6ccccc6)C5)ccn4)c3F)C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C007381

FormulaC28H25FN4O3

Molecular weight484.531

InChIKeyOHSPSWUQMQUVMW-UHFFFAOYSA-N

Physicochemical properties

Exact mass484.1911

RDKit cLogP3.25

TPSA82.6

HBD / HBA1 / 5

Rotatable bonds5

Heavy atoms36

Hetero atoms8

Rings / aromatic6 / 3

Fraction Csp30.29

Formal charge0

Fragments1

Activity compounds and values

Activity records

70 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	39	%	Concentration context: titrated doses	24 h	IKZF3	-	-	CN121646585A	PGDB_A011804	PGDB_C007381	PGDB_AS001615	View
DC50	-	=	2.9	nM	-	—	IKZF2	-	Jurkat	CN121646585A	PGDB_A012401	PGDB_C007381	PGDB_AS000135	View
DC50	-	>	1000	nM	-	—	IKZF1	-	-	CN121646585A	PGDB_A013040	PGDB_C007381	PGDB_AS001672	View
DC50	-	=	0.1	nM	-	—	IKZF4	-	-	CN121646585A	PGDB_A013101	PGDB_C007381	PGDB_AS000563	View
DC50	-	>	10000	nM	-	—	IKZF3	-	Jurkat	CN121646585A	PGDB_A016332	PGDB_C007381	PGDB_AS001077	View
% Degradation	-	=	39	%	Concentration context: titrated doses	24 h	IKZF3	-	-	CN121487946A	PGDB_A016920	PGDB_C007381	PGDB_AS002005	View
DC50	-	>	10000	nM	-	—	IKZF1	-	Jurkat	CN121646585A	PGDB_A017032	PGDB_C007381	PGDB_AS002085	View
Dmax	-	=	13	%	-	72 h	IKZF1	-	Jurkat	CN121487946A	PGDB_A019691	PGDB_C007381	PGDB_AS002502	View
Dmax	-	=	64	%	-	20 h	IKZF4	-	-	WO2025064197	PGDB_A019959	PGDB_C007381	PGDB_AS001958	View
DC50	-	=	2.9	nM	-	—	IKZF2	-	Jurkat	WO2025064197	PGDB_A020471	PGDB_C007381	PGDB_AS001529	View
Dmax	-	=	14	%	-	24 h	IKZF3	-	Jurkat	WO2025064197	PGDB_A020786	PGDB_C007381	PGDB_AS002580	View
DC50	-	>	1000	nM	-	—	IKZF3	-	-	CN121487946A	PGDB_A021039	PGDB_C007381	PGDB_AS001183	View
DC50	-	=	2.2	nM	-	—	IKZF2	-	-	CN121646585A	PGDB_A021302	PGDB_C007381	PGDB_AS001453	View
DC50	-	=	2.9	nM	-	—	IKZF2	-	Jurkat	CN121487946A	PGDB_A022356	PGDB_C007381	PGDB_AS001637	View
DC50	-	>	10000	nM	-	—	IKZF1	-	Jurkat	CN121487946A	PGDB_A023192	PGDB_C007381	PGDB_AS000485	View
DC50	-	>	10000	nM	-	—	IKZF1	-	-	CN121646585A	PGDB_A023263	PGDB_C007381	PGDB_AS001153	View
Dmax	-	=	92	%	-	-	IKZF2	-	-	CN121487946A	PGDB_A024156	PGDB_C007381	PGDB_AS000749	View
Dmax	-	=	88	%	-	24 h	IKZF2	-	Jurkat	WO2025064197	PGDB_A028368	PGDB_C007381	PGDB_AS001517	View
Dmax	-	=	92	%	-	13 d	IKZF4	-	-	CN121646585A	PGDB_A028676	PGDB_C007381	PGDB_AS000779	View
Dmax	-	=	20	%	-	24 h	IKZF1	-	-	CN121646585A	PGDB_A028986	PGDB_C007381	PGDB_AS000956	View

Rows per pagePage 1 of 4 · 70 recordsGo to page