Activity record

PGDB_A044666

Assay: % DegradationTarget: GSPT1QC: standardized
Activity overview

degradation = 25-50 %

TargetGSPT1
Cell lineKG-1
Concentration200 nM
Time4 h
Assay / ReadoutWestern_blot / % Degradation
Assay IDPGDB_AS001739
PatentWO2024251301A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C007916
Compound IDPGDB_C007916
CompoundNX-3
Source record IDPGDB_C007916
InChIKeyJFPDHRFBHTXINQ-MTDXEUNCSA-N

Assay context

Assay IDPGDB_AS001739
Assay family% Degradation
Assay systemcell_based
Readout% Degradation
TechnologyWestern_blot
Concentration200 nM
Treatment time4 h
Detection targetprotein_degradation
TargetGSPT1
E3Not specified
Cell lineKG-1

Source evidence

Patent IDWO2024251301A1
Compound location

NX-3

NX-3 enlarged structureNX-3 location on patent page 15
Activity table
Page 20 · table single