Activity record

PGDB_A045381

Assay: cellular_functionTarget: BRD4QC: ambiguous
Activity overview

EC50 = 47.93 uM

TargetBRD4
E3 ligaseCRBN
Cell lineFlip-InTM293
Time5 h
Assay / Readoutflow_cytometry / EC50
Assay IDPGDB_AS001859
PatentUS12110292B2
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C008989
Compound IDPGDB_C008989
Compound2;2;2
Source record IDPGDB_C008989
InChIKeyJOQAWPOOESVMFX-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001859
Assay familycellular_function
Assay systemcell_based
ReadoutEC50
Technologyflow_cytometry
Treatment time5 h
TargetBRD4
E3CRBN
Cell lineFlip-InTM293
Organismmammalian

Source evidence

Patent IDUS12110292B2
Compound location

2;2;2

2;2;2 enlarged structure2;2;2 location on patent page 26
Activity table
Page 102 · table start
Page 103 · table end