Activity record

PGDB_A045625

Assay: % DegradationTarget: GSPT1QC: ambiguous
Activity overview

EC50 < 1 uM

TargetGSPT1
E3 ligaseCRBN
Cell lineHEK293
Time4 h
Assay / Readoutluminescence / EC50
Assay IDPGDB_AS000168
PatentWO2022066835A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C001361
Compound IDPGDB_C001361
Compound1;1;1
Source record IDPGDB_C001361
InChIKeyRKAFYSIKAVFVPS-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000168
Assay family% Degradation
Assay systemcell_based
ReadoutEC50
Technologyluminescence
Treatment time4 h
TargetGSPT1
E3CRBN
Cell lineHEK293
OrganismHomo sapiens

Source evidence

Patent IDWO2022066835A1
Compound location

1;1;1

1;1;1 enlarged structure1;1;1 location on patent page 152
Activity table
Page 166 · table single