Activity record

PGDB_A045931

Assay: % DegradationTarget: IKZF3QC: ambiguous
Activity overview

DC50 = 21 nM

TargetIKZF3
Time24 h
Assay / Readoutflow_cytometry / DC50
Assay IDPGDB_AS002428
PatentWO2025049840
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C007372
Compound IDPGDB_C007372
CompoundComparative Compound A
Source record IDPGDB_C007372
InChIKeyCNNZMWHBTVDISB-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS002428
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyflow_cytometry
Treatment time24 h
Detection targetprotein_degradation
TargetIKZF3
E3Not specified
OrganismHomo sapiens

Source evidence

Patent IDWO2025049840
Compound location

Comparative Compound A

Comparative Compound A enlarged structureComparative Compound A location on patent page 100
Activity table
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