PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2025049840

AssigneeBristol Myers Squibb

TitleSubstituted phenyl oxooxazolyl piperidine dione compounds

Family ID92931757

Family members8

Filing year2024

Publication date2025-03-06

JurisdictionWO

Compounds7

Activity records164

Assays26

Activity compounds and values

Activity records

164 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
DC50	-	=	15	nM	-	—	-	-	primary human PBMC	PGDB_A007030	PGDB_C010128	PGDB_AS001952	View
Dmax	-	=	0	%	-	-	IKZF4	-	-	PGDB_A007319	PGDB_C007372	PGDB_AS001208	View
Dmax	-	=	77	%	-	-	IKZF3	-	-	PGDB_A007335	PGDB_C010128	PGDB_AS001160	View
Dmax	-	=	91	%	-	-	IKZF2	-	Jurkat	PGDB_A008259	PGDB_C010128	PGDB_AS000207	View
% Degradation	-	=	67	%	Concentration context: titrated doses	24 h	-	-	primary human PBMC	PGDB_A008684	PGDB_C010127	PGDB_AS001028	View
Dmax	-	=	56	%	-	20 h	IKZF1	-	-	PGDB_A008882	PGDB_C010126	PGDB_AS001762	View
DC50	-	=	34	nM	-	—	IKZF2	-	Jurkat	PGDB_A008896	PGDB_C010128	PGDB_AS002487	View
Dmax	-	=	52	%	-	20 h	IKZF1	-	-	PGDB_A009600	PGDB_C010129	PGDB_AS001762	View
DC50	-	=	37	nM	-	—	IKZF2	-	Jurkat	PGDB_A009930	PGDB_C010126	PGDB_AS002487	View
Dmax	-	=	98	%	-	20 h	IKZF2	-	-	PGDB_A010166	PGDB_C010126	PGDB_AS002476	View
DC50	-	=	247	nM	-	—	IKZF2	-	-	PGDB_A010425	PGDB_C010127	PGDB_AS001132	View
DC50	-	=	131	nM	-	—	IKZF3	-	-	PGDB_A010524	PGDB_C010129	PGDB_AS002428	View
Dmax	-	=	80	%	-	-	IKZF3	-	-	PGDB_A010563	PGDB_C007372	PGDB_AS001160	View
Dmax	-	=	48	%	-	24 h	IKZF3	-	Jurkat	PGDB_A010979	PGDB_C010126	PGDB_AS000726	View
Dmax	-	=	69	%	-	24 h	IKZF1	-	Jurkat	PGDB_A011542	PGDB_C010128	PGDB_AS000717	View
Dmax	-	=	27	%	-	24 h	IKZF2	-	Jurkat	PGDB_A012567	PGDB_C007372	PGDB_AS001341	View
Dmax	-	=	98	%	-	20 h	IKZF2	-	-	PGDB_A014522	PGDB_C010125	PGDB_AS002476	View
Dmax	-	=	74	%	-	13 d	IKZF2	-	-	PGDB_A014897	PGDB_C010126	PGDB_AS001641	View
Dmax	-	=	27	%	-	-	IKZF2	-	Jurkat	PGDB_A015540	PGDB_C007372	PGDB_AS000207	View
Dmax	-	=	98	%	-	20 h	IKZF2	-	-	PGDB_A015776	PGDB_C010128	PGDB_AS002476	View

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