PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(n2cc(-c3ccccc3)oc2=O)C(=O)N1

Compound summary

Compound IDPGDB_C007372

FormulaC14H12N2O4

Molecular weight272.26

InChIKeyCNNZMWHBTVDISB-UHFFFAOYSA-N

Physicochemical properties

Exact mass272.0797

RDKit cLogP1.09

TPSA81.3

HBD / HBA1 / 5

Rotatable bonds2

Heavy atoms20

Hetero atoms6

Rings / aromatic3 / 2

Fraction Csp30.21

Formal charge0

Fragments1

Activity compounds and values

Activity records

58 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	0	%	-	-	IKZF4	-	-	WO2025049840	PGDB_A007319	PGDB_C007372	PGDB_AS001208	View
Dmax	-	=	74	%	Concentration context: titrated doses	24 h	IKZF1	-	-	CN121368591A	PGDB_A008524	PGDB_C007372	PGDB_AS002355	View
Dmax	-	=	1	%	-	-	IKZF2	-	-	US20250129061A1	PGDB_A009448	PGDB_C007372	PGDB_AS001318	View
Dmax	-	=	80	%	-	-	IKZF3	-	-	WO2025049840	PGDB_A010563	PGDB_C007372	PGDB_AS001160	View
Dmax	-	=	74	%	-	-	IKZF1	-	-	US20250129061A1	PGDB_A011569	PGDB_C007372	PGDB_AS000475	View
Dmax	-	=	27	%	-	72 h	IKZF2	-	Jurkat	CN121368591A	PGDB_A012062	PGDB_C007372	PGDB_AS002303	View
DC50	-	=	1520	nM	-	—	IKZF1	-	Jurkat	CN121368591A	PGDB_A012396	PGDB_C007372	PGDB_AS000891	View
Dmax	-	=	27	%	-	24 h	IKZF2	-	Jurkat	WO2025049840	PGDB_A012567	PGDB_C007372	PGDB_AS001341	View
Dmax	-	=	46	%	-	72 h	IKZF3	-	Jurkat	US20250129061A1	PGDB_A013555	PGDB_C007372	PGDB_AS001493	View
Dmax	-	=	0	%	Concentration context: titrated doses	13 d	IKZF4	-	-	US20250129061A1	PGDB_A013796	PGDB_C007372	PGDB_AS000732	View
DC50	-	=	1520	nM	-	—	IKZF1	-	Jurkat	US20250129061A1	PGDB_A013830	PGDB_C007372	PGDB_AS002138	View
Dmax	-	=	27	%	-	-	IKZF2	-	Jurkat	WO2025049840	PGDB_A015540	PGDB_C007372	PGDB_AS000207	View
DC50	-	=	113	nM	-	—	IKZF1	-	-	US20250129061A1	PGDB_A018378	PGDB_C007372	PGDB_AS000255	View
Dmax	-	=	74	%	Concentration context: titrated doses of compound	24 h	IKZF1	-	-	US20250129061A1	PGDB_A018920	PGDB_C007372	PGDB_AS001411	View
DC50	-	>	10000	nM	-	—	IKZF3	-	Jurkat	WO2025049840	PGDB_A020071	PGDB_C007372	PGDB_AS000098	View
Dmax	-	=	70	%	-	24 h	IKZF1	-	Jurkat	WO2025049840	PGDB_A020120	PGDB_C007372	PGDB_AS000717	View
Dmax	-	=	1	%	Concentration context: titrated doses	13 d	IKZF2	-	-	CN121368591A	PGDB_A020560	PGDB_C007372	PGDB_AS002527	View
% Degradation	-	=	74	%	Concentration context: titrated doses of compound	24 h	IKZF1	-	-	CN121368591A	PGDB_A021804	PGDB_C007372	PGDB_AS001917	View
DC50	-	>	1000	nM	-	—	IKZF2	-	-	US20250129061A1	PGDB_A023081	PGDB_C007372	PGDB_AS000731	View
DC50	-	>	10000	nM	-	—	IKZF2	-	Jurkat	US20250129061A1	PGDB_A026179	PGDB_C007372	PGDB_AS001143	View

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