Activity record

PGDB_A047030

Assay: % DegradationTarget: GSPT1QC: standardized
Activity overview

DC50 = 21 nM

TargetGSPT1
Cell lineNB4
Time4 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS001663
PatentWO2024222614A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C003193
Compound IDPGDB_C003193
Compound19;19
Source record IDPGDB_C003193
InChIKeyDOXFDZLEHUBOGC-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001663
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time4 h
Detection targetprotein_degradation
TargetGSPT1
E3Not specified
Cell lineNB4

Source evidence

Patent IDWO2024222614A1
Compound location

19;19

19;19 enlarged structure19;19 location on patent page 13
Activity table
Page 62 · table start
Page 63 · table end