PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2024222614A1

AssigneeBeijing Innocare Pharma Tech

TitleHeterocyclic gspt1 degradation agent

Family ID93255584

Family members2

Filing year2024

Publication date2024-10-31

JurisdictionWO

Compounds44

Activity records119

Assays4

Activity compounds and values

Activity records

119 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
DC50	-	=	7.2	nM	-	—	GSPT1	-	NB4	PGDB_A007290	PGDB_C003182	PGDB_AS001663	View
GI50	-	=	22	nM	-	—	GSPT1	-	NCI-H1155	PGDB_A007848	PGDB_C003214	PGDB_AS000187	View
DC50	-	>	1000	nM	-	—	GSPT1	-	NB4	PGDB_A008465	PGDB_C003200	PGDB_AS001663	View
Dmax	-	=	125	%	-	4 h	GSPT1	-	NB4	PGDB_A008622	PGDB_C003217	PGDB_AS000251	View
GI50	-	=	39	nM	-	—	GSPT1	-	NCI-H1155	PGDB_A009532	PGDB_C003210	PGDB_AS000187	View
Dmax	-	=	112	%	-	4 h	GSPT1	-	NB4	PGDB_A010052	PGDB_C003186	PGDB_AS000251	View
DC50	-	=	15	nM	-	—	GSPT1	-	NB4	PGDB_A013016	PGDB_C003197	PGDB_AS001663	View
GI50	-	=	35	nM	-	—	GSPT1	-	NB4	PGDB_A013366	PGDB_C003183	PGDB_AS001086	View
Dmax	-	=	94	%	-	4 h	GSPT1	-	NB4	PGDB_A013551	PGDB_C003181	PGDB_AS000251	View
GI50	-	=	4.5	nM	-	—	GSPT1	-	NB4	PGDB_A014707	PGDB_C003184	PGDB_AS001086	View
Dmax	-	=	113	%	-	4 h	GSPT1	-	NB4	PGDB_A015376	PGDB_C003184	PGDB_AS000251	View
GI50	-	=	33	nM	-	—	GSPT1	-	NB4	PGDB_A016267	PGDB_C003175	PGDB_AS001086	View
GI50	-	=	10	nM	-	—	GSPT1	-	NCI-H1155	PGDB_A017336	PGDB_C003207	PGDB_AS000187	View
Dmax	-	=	16	%	-	4 h	GSPT1	-	NB4	PGDB_A017501	PGDB_C003196	PGDB_AS000251	View
DC50	-	=	4.8	nM	-	—	GSPT1	-	NB4	PGDB_A019557	PGDB_C003201	PGDB_AS001663	View
GI50	-	=	23	nM	-	—	GSPT1	-	NB4	PGDB_A019808	PGDB_C003181	PGDB_AS001086	View
GI50	-	=	23	nM	-	—	GSPT1	-	NB4	PGDB_A022412	PGDB_C003190	PGDB_AS001086	View
DC50	-	=	5.2	nM	-	—	GSPT1	-	NB4	PGDB_A023306	PGDB_C003181	PGDB_AS001663	View
DC50	-	>	1000	nM	-	—	GSPT1	-	NB4	PGDB_A023514	PGDB_C003177	PGDB_AS001663	View
GI50	-	=	19	nM	-	—	GSPT1	-	NCI-H1155	PGDB_A023941	PGDB_C003216	PGDB_AS000187	View

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