Activity record

PGDB_A052714

Assay: % DegradationTarget: IKZF1QC: ambiguous
Activity overview

Dmax = 73.6 %

TargetIKZF1
Cell lineNCI-H929
ConcentrationConcentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM
Time24 h
Assay / ReadoutDmax / % Degradation
Assay IDPGDB_AS000833
PatentCA3286762A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C025600
Compound IDPGDB_C025600
CompoundExample 4
Source record IDPGDB_C006156
InChIKeyXIYNYSWXUIJVDD-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000833
Assay family% Degradation
Assay systemcell_based
ReadoutDmax
ConcentrationConcentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM
Treatment time24 h
Detection targetprotein_degradation
TargetIKZF1
E3Not specified
Cell lineNCI-H929

Source evidence

Patent IDCA3286762A1
Compound location

Example 4

Example 4 enlarged structureExample 4 location on patent page 65
Activity table
Page 102 · table single