Activity record

PGDB_A054101

Assay: % DegradationTarget: IKZF1QC: ambiguous
Activity overview

degradation = 0-25 %

TargetIKZF1
Cell lineNCI-H929
Concentration1 uM
Time24 h
Assay / ReadoutWestern_blot / % Degradation
Assay IDPGDB_AS000181
PatentWO2022146151A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C009602
Compound IDPGDB_C009602
CompoundThalidomide
Source record IDPGDB_C000103
InChIKeyUEJJHQNACJXSKW-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000181
Assay family% Degradation
Assay systemcell_based
Readout% Degradation
TechnologyWestern_blot
Concentration1 uM
Treatment time24 h
TargetIKZF1
E3Not specified
Cell lineNCI-H929
OrganismHomo sapiens

Source evidence

Patent IDWO2022146151A1
Compound location

Thalidomide

Thalidomide enlarged structureThalidomide location on patent page 81
Activity table
Page 86 · table single