PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2022146151A1

AssigneeCaptor Therapeutics

TitleNovel compounds which bind to cereblon, and methods of use thereof

Family ID74347684

Family members8

Filing year2020

Publication date2022-07-07

JurisdictionWO

Compounds25

Activity records42

Assays12

Activity compounds and values

Activity records

42 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
Ki	-	=	1-5	uM	-	—	CRBN	CRBN	-	PGDB_A008671	PGDB_C009603	PGDB_AS002364	View
% Degradation	-	=	26-74	%	20 uM	24 h	IKZF1	CRBN	NCI-H929	PGDB_A009288	PGDB_C009602	PGDB_AS000759	View
% Degradation	-	>	25	%	1 uM	24 h	IKZF3	-	NCI-H929	PGDB_A011324	PGDB_C009603	PGDB_AS001915	View
% Degradation	-	=	75-100	%	10 uM	24 h	IKZF1	-	NCI-H929	PGDB_A011985	PGDB_C009603	PGDB_AS001123	View
Ki	-	=	1-5	uM	-	—	CRBN	CRBN	-	PGDB_A011992	PGDB_C008731	PGDB_AS002364	View
Ki	-	=	1-5	uM	-	—	CRBN	CRBN	-	PGDB_A012536	PGDB_C009611	PGDB_AS002364	View
Ki	-	<=	1	uM	-	—	CRBN	CRBN	-	PGDB_A013255	PGDB_C009610	PGDB_AS002364	View
Ki	-	<=	1	uM	-	—	CRBN	CRBN	-	PGDB_A014071	PGDB_C009616	PGDB_AS002364	View
Ki	-	<=	1	uM	-	—	CRBN	CRBN	-	PGDB_A015276	PGDB_C009617	PGDB_AS002364	View
Ki	-	<=	1	uM	-	—	CRBN	CRBN	-	PGDB_A020502	PGDB_C009619	PGDB_AS002364	View
Ki	-	=	1-5	uM	-	—	CRBN	CRBN	-	PGDB_A022447	PGDB_C009622	PGDB_AS002364	View
% Degradation	-	=	0-25	%	10 uM	24 h	IKZF1	-	NCI-H929	PGDB_A024727	PGDB_C009602	PGDB_AS001123	View
Ki	-	<=	1	uM	-	—	CRBN	CRBN	-	PGDB_A026969	PGDB_C019024	PGDB_AS002364	View
% Degradation	-	<=	25	%	1 uM	24 h	IKZF3	-	NCI-H929	PGDB_A029642	PGDB_C009602	PGDB_AS001915	View
Ki	-	=	5-10	uM	-	—	CRBN	CRBN	-	PGDB_A030799	PGDB_C009608	PGDB_AS002364	View
Ki	-	=	1-5	uM	-	—	CRBN	CRBN	-	PGDB_A031087	PGDB_C009609	PGDB_AS002364	View
Ki	-	=	1-5	uM	-	—	CRBN	CRBN	-	PGDB_A033268	PGDB_C009614	PGDB_AS002364	View
Ki	-	<=	1	uM	-	—	CRBN	CRBN	-	PGDB_A034019	PGDB_C009613	PGDB_AS002364	View
Ki	-	<=	1	uM	-	—	CRBN	CRBN	-	PGDB_A034274	PGDB_C009601	PGDB_AS002364	View
Ki	-	=	1-5	uM	-	—	CRBN	CRBN	-	PGDB_A037695	PGDB_C009623	PGDB_AS002364	View

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