Activity record

PGDB_A057604

Assay: % DegradationQC: standardized
Activity overview

DC50 = 0.38 nM

Cell lineNCI-H929
Time24 h
Assay / ReadoutWestern_blot / DC50
Assay IDPGDB_AS001024
PatentEP4685141A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C025600
Compound IDPGDB_C025600
Compound实施例 4
Source record IDPGDB_C025600
InChIKeyXIYNYSWXUIJVDD-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001024
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
TechnologyWestern_blot
Treatment time24 h
Detection targetprotein_degradation
TargetIKZF1
E3Not specified
Cell lineNCI-H929
OrganismHomo sapiens

Source evidence

Patent IDEP4685141A1
Compound location

实施例 4

实施例 4 enlarged structure实施例 4 location on patent page 44
Activity table
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