Activity record

PGDB_A058014

Assay: viabilityTarget: KRASQC: standardized
Activity overview

IC50 = 0.2651 nM

TargetKRAS
Cell lineNCI-H358
Time5 d
Assay / ReadoutCCK-8 / IC50
Assay IDPGDB_AS000944
PatentWO2025214350A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C011632
Compound IDPGDB_C011632
CompoundRef.3
Source record IDPGDB_C011632
InChIKeyMLOJXARVLWJYNZ-AAHLPCHMSA-N

Assay context

Assay IDPGDB_AS000944
Assay familyviability
Assay systemcell_based
ReadoutIC50
TechnologyCCK-8
Treatment time5 d
Detection target% Cell viability
TargetKRAS
E3Not specified
Cell lineNCI-H358
OrganismHomo sapiens

Source evidence

Patent IDWO2025214350A1
Compound location

Ref.3

Ref.3 enlarged structureRef.3 location on patent page 220
Activity table
Page 226 · table single