PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2025214350A1

AssigneeSunrise Oncology Hong Kong

TitleMacrocyclic compounds as ras inhibitors for the treatment of cancer

Family ID97349403

Family members1

Filing year2025

Publication date2025-10-16

JurisdictionWO

Compounds99

Activity records599

Assays16

Activity compounds and values

Activity records

599 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	100-1000	nM	-	—	KRAS	-	AGS	PGDB_A007012	PGDB_C011618	PGDB_AS000218	View
IC50	-	<=	1	nM	-	—	KRAS	-	SW620	PGDB_A007085	PGDB_C011597	PGDB_AS001156	View
IC50	-	=	1-10	nM	-	—	KRAS	-	-	PGDB_A007110	PGDB_C011598	PGDB_AS001818	View
IC50	-	=	10-100	nM	-	—	KRAS	-	-	PGDB_A007143	PGDB_C011590	PGDB_AS001818	View
IC50	-	=	1-10	nM	-	—	KRAS	-	-	PGDB_A007326	PGDB_C011598	PGDB_AS000928	View
IC50	-	=	1-10	nM	-	—	-	-	AsPC-1	PGDB_A007661	PGDB_C011612	PGDB_AS001410	View
IC50	-	=	10-100	nM	-	—	KRAS	-	-	PGDB_A007755	PGDB_C011617	PGDB_AS002054	View
IC50	-	=	1-10	nM	-	—	KRAS	-	HPAC	PGDB_A008068	PGDB_C011631	PGDB_AS002124	View
IC50	-	=	5.017	nM	-	—	KRAS	-	NCI-H358	PGDB_A008260	PGDB_C011587	PGDB_AS000944	View
IC50	-	=	1-10	nM	-	—	KRAS	-	-	PGDB_A008365	PGDB_C011625	PGDB_AS002054	View
IC50	-	=	10-100	nM	-	—	KRAS	-	-	PGDB_A008927	PGDB_C011589	PGDB_AS000307	View
IC50	-	=	1-10	nM	-	—	KRAS	-	AGS	PGDB_A009159	PGDB_C011675	PGDB_AS000218	View
IC50	-	>	1000	nM	-	—	BRAF	-	A375	PGDB_A009173	PGDB_C011633	PGDB_AS001949	View
IC50	-	=	1-10	nM	-	—	KRAS	-	NCI-H358	PGDB_A009247	PGDB_C011624	PGDB_AS001442	View
IC50	-	=	1-10	nM	-	—	KRAS	-	-	PGDB_A009637	PGDB_C011606	PGDB_AS000928	View
IC50	-	=	1-10	nM	-	—	KRAS	-	-	PGDB_A009797	PGDB_C011624	PGDB_AS002054	View
IC50	-	=	100-1000	nM	-	—	KRAS	-	NCI-H358	PGDB_A009873	PGDB_C011621	PGDB_AS001442	View
IC50	-	<=	1	nM	-	—	KRAS	-	SW620	PGDB_A009895	PGDB_C011612	PGDB_AS001156	View
IC50	-	=	1-10	nM	-	—	KRAS	-	-	PGDB_A009952	PGDB_C011595	PGDB_AS000928	View
IC50	-	=	10-100	nM	-	—	KRAS	-	AGS	PGDB_A010197	PGDB_C011647	PGDB_AS000218	View

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