Activity record

PGDB_A060800

Assay: % DegradationTarget: BRAFQC: ambiguous
Activity overview

DC50 = 17.72 nM

TargetBRAF
Cell lineA375.10
Time24 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS001629
PatentAU2022290851A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C005757
Compound IDPGDB_C005757
CompoundExample 105
Source record IDPGDB_C005757
InChIKeyQZTRUCJKMVKTPL-RWYGWLOXSA-N

Assay context

Assay IDPGDB_AS001629
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time24 h
TargetBRAF
E3Not specified
Cell lineA375.10

Source evidence

Patent IDAU2022290851A1
Compound location

Example 105

Example 105 enlarged structureExample 105 location on patent page 532
Activity table
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