Activity record

PGDB_A060842

Assay: % DegradationTarget: BRAFQC: standardized
Activity overview

Emax = 9.75 %

TargetBRAF
Cell lineA375.10
Concentration10 uM
Time24 h
Assay / Readoutluminescence / Emax
Assay IDPGDB_AS000362
PatentAU2022290851A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C005807
Compound IDPGDB_C005807
CompoundExample 155
Source record IDPGDB_C005807
InChIKeyLPJSUMNVPGPKHQ-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000362
Assay family% Degradation
Assay systemcell_based
ReadoutEmax
Technologyluminescence
Concentration10 uM
Treatment time24 h
TargetBRAF
E3Not specified
Cell lineA375.10

Source evidence

Patent IDAU2022290851A1
Compound location

Example 155

Example 155 enlarged structureExample 155 location on patent page 611
Activity table
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