Activity record

PGDB_A061288

Assay: % DegradationTarget: BRAFQC: standardized
Activity overview

DC50 = 20.06 nM

TargetBRAF
Cell lineA375.10
Time24 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS001091
PatentAU2022290851A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C005732
Compound IDPGDB_C005732
CompoundExample 79
Source record IDPGDB_C005732
InChIKeyFNGGPOAKRYCRLX-FIMWSPJOSA-N

Assay context

Assay IDPGDB_AS001091
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time24 h
TargetBRAF
E3Not specified
Cell lineA375.10

Source evidence

Patent IDAU2022290851A1
Compound location

Example 79

Example 79 enlarged structureExample 79 location on patent page 465
Activity table
Page 228 · table start