Activity record

PGDB_A065165

Assay: % DegradationTarget: GSPT1QC: standardized
Activity overview

DC50 = 3.8 nM

TargetGSPT1
Cell lineNB4
Time4 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS001663
PatentWO2024222614A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C003218
Compound IDPGDB_C003218
Compound44;44
Source record IDPGDB_C003218
InChIKeyITFOBEGZUHUCDY-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001663
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time4 h
Detection targetprotein_degradation
TargetGSPT1
E3Not specified
Cell lineNB4

Source evidence

Patent IDWO2024222614A1
Compound location

44;44

44;44 enlarged structure44;44 location on patent page 18
Activity table
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