Activity record

PGDB_A069995

Assay: % DegradationTarget: BRAFQC: ambiguous
Activity overview

DC50 = 27.1 nM

TargetBRAF
Cell lineA375.10
Time24 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS001629
PatentAU2022290851A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C005774
Compound IDPGDB_C005774
CompoundExample 122
Source record IDPGDB_C005774
InChIKeyUGTSXYVNZRJAOK-QNGWXLTQSA-N

Assay context

Assay IDPGDB_AS001629
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time24 h
TargetBRAF
E3Not specified
Cell lineA375.10

Source evidence

Patent IDAU2022290851A1
Compound location

Example 122

Example 122 enlarged structureExample 122 location on patent page 549
Activity table
Page 229 · table start
Page 230 · table end