Activity record

PGDB_A070050

Assay: % DegradationTarget: IKZF3QC: standardized
Activity overview

DC50 <= 0.1 nM

TargetIKZF3
E3 ligaseCRBN
Time24 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS002421
PatentWO2025195464A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C011554
Compound IDPGDB_C011554
CompoundCM-229-P1A
Source record IDPGDB_C011554
InChIKeyLKHKYOFXRUKRPG-QIKUIUABSA-N

Assay context

Assay IDPGDB_AS002421
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time24 h
Detection targetprotein_degradation
TargetIKZF3
E3CRBN
OrganismHomo sapiens

Source evidence

Patent IDWO2025195464A1
Compound location

CM-229-P1A

CM-229-P1A enlarged structureCM-229-P1A location on patent page 129
Activity table
Page 151 · table single