Activity record

PGDB_A074636

Assay: viabilityTarget: KRASQC: standardized
Activity overview

IC50 = 0.1301 nM

TargetKRAS
Cell lineHPAC
Time5-day treatment
Assay / ReadoutCCK-8 / IC50
Assay IDPGDB_AS000104
PatentWO2025214350A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C011605
Compound IDPGDB_C011605
CompoundExample 18
Source record IDPGDB_C011605
InChIKeyQDFUYTVFSGSPQA-FQDQCCRJSA-N

Assay context

Assay IDPGDB_AS000104
Assay familyviability
Assay systemcell_based
ReadoutIC50
TechnologyCCK-8
Treatment time5-day treatment
Detection target% Cell viability
TargetKRAS
E3Not specified
Cell lineHPAC
OrganismHomo sapiens

Source evidence

Patent IDWO2025214350A1
Compound location

Example 18

Example 18 enlarged structureExample 18 location on patent page 58
Activity table
Page 226 · table single