Activity record

PGDB_A077137

Assay: % DegradationTarget: BRAFQC: standardized
Activity overview

DC50 = 10.6 nM

TargetBRAF
Cell lineA375.10
Time24 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS001308
PatentAU2022290851A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C005797
Compound IDPGDB_C005797
CompoundExample 145
Source record IDPGDB_C005797
InChIKeyKRIKLPOXODZVRU-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001308
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time24 h
TargetBRAF
E3Not specified
Cell lineA375.10

Source evidence

Patent IDAU2022290851A1
Compound location

Example 145

Example 145 enlarged structureExample 145 location on patent page 590
Activity table
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