Activity record

PGDB_A077762

Assay: % DegradationTarget: BRAFQC: standardized
Activity overview

DC50 = 18.73 nM

TargetBRAF
Cell lineA375.10
Time24 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS001091
PatentAU2022290851A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C005698
Compound IDPGDB_C005698
CompoundExample 45
Source record IDPGDB_C005698
InChIKeyKUKQPXQWBSIDQC-MFIBOOTFSA-N

Assay context

Assay IDPGDB_AS001091
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time24 h
TargetBRAF
E3Not specified
Cell lineA375.10

Source evidence

Patent IDAU2022290851A1
Compound location

Example 45

Example 45 enlarged structureExample 45 location on patent page 389
Activity table
Page 228 · table start