Activity record

PGDB_A079188

Assay: % DegradationTarget: KRASQC: ambiguous
Activity overview

DC50 = 6.9 nM

TargetKRAS
Time18 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS001045
PatentWO2026114958A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C031961
Compound IDPGDB_C031961
CompoundI-21
Source record IDPGDB_C031961
InChIKeyLWEDITBOFULPNR-LGWOJERMSA-N

Assay context

Assay IDPGDB_AS001045
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time18 h
TargetKRAS
E3Not specified
OrganismHomo sapiens

Source evidence

Patent IDWO2026114958A1
Compound location

I-21

I-21 enlarged structureI-21 location on patent page 251
Activity table
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